Sodium Hydroxide → 6-(4-Methoxyphenyl)nicotinic acid

Reaktionsgleichung

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:18]=[CH:17][C:12]([C:13]([O:15]C)=[O:14])=[CH:11][N:10]=2)=[CH:5][CH:4]=1.[OH-].[Na+]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:18]=[CH:17][C:12]([C:13]([OH:15])=[O:14])=[CH:11][N:10]=2)=[CH:7][CH:8]=1

Komponenten

Edukt 2

HCID 14798Sodium Hydroxide

HCID 18625729HCID 18625729, Verbindung

Produkt 1

HCID 186259336-(4-Methoxyphenyl)nicotinic acidAusbeute 70,7 %

Versuchsvorschrift

In a similar manner to that described in Example 2, a reaction was carried out using methyl 6-(4-methoxyphenyl)nicotinate (3.95 g) and aqueous sodium hydroxide solution (1N, 32.5 ml) and the reaction mixture was treated to afford the title compound (2.63 g) as colorless crystals.

Aufarbeitung

additionthe reaction mixture was treated

Quellen und Nachweise

ORD-Eintrag: ord-e70ca072ff05452e8dda5e203b16360c
Quelldatensatz: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06528525B1

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