Sodium Hydroxide → 6-(4-Fluorophenyl)nicotinic acid

HRID 1860037Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1860037
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14]C)=[O:13])=[CH:10][N:9]=2)=[CH:4][CH:3]=1.[OH-].[Na+]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([OH:14])=[O:13])=[CH:10][N:9]=2)=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 14798Sodium HydroxideHCID 110317126-(4-Fluorophenyl)pyridine-3-carboxylic acid methyl ester

Produkt 1

HCID 227301866-(4-Fluorophenyl)nicotinic acidAusbeute 94,2 %

Versuchsvorschrift

In a similar manner to that described in Example 2, a reaction was carried out using methyl 6-(4-fluorophenyl)nicotinate (390 mg) and aqueous sodium hydroxide solution (1N, 5.00 ml) and the reaction mixture was treated to afford the title compound (345 mg) as a pale yellow solid.

Aufarbeitung

  1. additionthe reaction mixture was treated

Quellen und Nachweise

ORD-Eintrag
ord-e68c8e300c7a42e58d9cf95081c2c404
Quelldatensatz
uspto-grants-2003_03
Patentnummer
US06528525B1

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