1,1'-Carbonyldiimidazole → HCID 18625863, Verbindung

Reaktionsgleichung

[NH2:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:12]=[CH:11][C:8]([CH2:9][OH:10])=[CH:7][CH:6]=1.[N:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:19]1[CH:27]=[CH:26][C:22]([C:23](O)=[O:24])=[CH:21][CH:20]=1.C(N1C=CN=C1)(N1C=CN=C1)=O>>[N:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:19]1[CH:20]=[CH:21][C:22]([C:23]([NH:1][CH2:2][CH2:3][CH2:4][C:5]2[CH:12]=[CH:11][C:8]([CH2:9][OH:10])=[CH:7][CH:6]=2)=[O:24])=[CH:26][CH:27]=1

Komponenten

Edukt 3

HCID 682631,1'-Carbonyldiimidazole

HCID 8216924-(2-Pyridyl)Benzoic Acid

HCID 13655334HCID 13655334, Verbindung

Produkt 1

HCID 18625863HCID 18625863, Verbindung

Versuchsvorschrift

Palladium on carbon (5%, 0.15 g) was added to a solution of 4-(3-benzyloxycarbonylaminopropyl)benzylalcohol (1.00 g), which is the product of Reference example 50(a) in ethanol (20 ml). The mixture was stirred under an atmosphere of hydrogen at ambient temperature for 2 hours. The catalyst was removed by filtration and the filtrate was concentrated to afford 4-(3-aminopropyl)benzylalcohol as a gum. In a similar manner to that described in Example 5, a reaction was carried out using 4-(3-aminopropyl)benzylalcohol, 4-pyridine-2-ylbenzoic acid (668 mg) and carbonyidiimidazole (650 mg) and the reaction mixture was treated to afford the desired compound (0.74 g) as colorless crystals.