Methylamine → N-methyl-4-chlorophthalimide
Reaktionsgleichung
[Cl:1][CH:2]1[CH:12]=[CH:11][CH:5]2[C:6]([O:8][C:9](=O)[CH:4]2[CH2:3]1)=[O:7].[CH3:13][NH2:14]>>[CH3:13][N:14]1[C:9](=[O:8])[C:4]2=[CH:3][C:2]([Cl:1])=[CH:12][CH:11]=[C:5]2[C:6]1=[O:7]Komponenten
3
Reaktionsbedingungen
- Temperatur
- 150 °C
Versuchsvorschrift
An appropriately equipped glass reaction vessel was charged with 186.5 grams (1 mole) of 4-chlorotetrahydrophthalic anhydride and heated to 150° C. under nitrogen. Methylamine gas (32 grams, 1.03 mole) was then introduced to the reaction vessel subsurface over 30 minutes. The reaction mixture was then heated for 3 hours at 180° C. The product was then distilled to give N-methyl-4-chlorophthalimide in approximately 95% yield.
Aufarbeitung
- customAn appropriately equipped glass reaction vessel
- temperatureThe reaction mixture was then heated for 3 hours at 180° C
- distillationThe product was then distilled
Quellen und Nachweise
- ORD-Eintrag
- ord-18a8d1327da74491bcd01ca1326c2c4b
- Quelldatensatz
- uspto-grants-2003_03
- Patentnummer
- US06528663B1
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