Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Pamidronic Acid | HCID 4674 | — |
| Edukt | Pamidronate Disodium Anhydrous | HCID 73351 | — |
| Edukt | Sodium ethoxide | HCID 2723922 | — |
| Edukt | Sodium | HCID 5360545 | — |
| Edukt | Sodium Methoxide | HCID 10942334 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Produkt | Pamidronate disodium hydrate | HCID 16078998 | — |
Reaktionsschritte
In the process for preparing crystalline disodium pamidronate from the reaction solution of neutralization of pamidronic acid with an organic sodium compound according to the second method, it is characterized to be included the process which pamidronic acid is neutralized with sodium methoxide or sodium ethoxide in absolute methanol or absolute ethanol under refluxing: the salt produced from neutralization is dissolved in water and the insoluble materials produced are filtered: the filtrate is allowed to stand at room temperature to induce crystallization: the resulting solution is slowly cooled and filtered to obtain the crystals: and then the resulting crystals are dried at temperature of 75˜85° C. under normal pressure to obtain the crystalline disodium pamidronate hydrate.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US06534674B2 |
|---|
| Quelldatensatz | uspto-grants-2003_03 |
|---|
| ORD ID | ord-034065f4d7b54650938756b96dd24b9c |
|---|
| Quellennotiz | uspto-grants-2003_03 |
|---|
