2-{1-(Methoxycarbonyl)ethoxy}-3-nitropyridine → 3-Amino-2-{1-(methoxycarbonyl)ethoxy}pyridine

HRID 1862261Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1862261
[CH3:1][O:2][C:3]([CH:5]([O:7][C:8]1[C:13]([N+:14]([O-])=O)=[CH:12][CH:11]=[CH:10][N:9]=1)[CH3:6])=[O:4]>[Pt]=O.C(O)C>[NH2:14][C:13]1[C:8]([O:7][CH:5]([C:3]([O:2][CH3:1])=[O:4])[CH3:6])=[N:9][CH:10]=[CH:11][CH:12]=1

Komponenten

4

Edukt 1

HCID 219335712-{1-(Methoxycarbonyl)ethoxy}-3-nitropyridine

Produkt 1

HCID 219335303-Amino-2-{1-(methoxycarbonyl)ethoxy}pyridineAusbeute 78,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 82844Platinum oxide (PtO)KatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 1.7 g of 2-{1-(methoxycarbonyl)ethoxy}-3-nitropyridine, 102 mg of platinum oxide and 7.5 ml of ethanol was stirred for 3.5 hours at room temperature under hydrogen atmosphere. The reaction system was purged with nitrogen, then, the reaction solution was filtrated through Celite, and the filtrate was concentrated. The residue was subjected to silica gel column chromatography to obtain 1.16 g of 3-amino-2-{1-(methoxycarbonyl)ethoxy}pyridine.

Aufarbeitung

  1. customThe reaction system was purged with nitrogen
  2. filtrationthe reaction solution was filtrated through Celite
  3. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-edfbf264ea944565820c9af1c7946d5e
Quelldatensatz
uspto-grants-2003_03
Patentnummer
US06537948B1

Notizen zur Reaktion

Wird geladen…