Hydrochloric Acid → 4-(Benzyloxy)pyridin-3-ol

HRID 1862274Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1862274
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][N:12]=[CH:11][C:10]=1[O:15]COC)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.C(=O)(O)[O-].[Na+]>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][N:12]=[CH:11][C:10]=1[OH:15])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 186191724-Benzyloxy-3-methoxymethoxypyridine

Produkt 1

HCID 186192064-(Benzyloxy)pyridin-3-olAusbeute 95,3 %

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A mixture of 0.7 g of 4-benzyloxy-3-methoxymethoxypyridine and 1N hydrochloric acid was stirred for 2 hours at 60° C. The mixture was poured into saturated aqueous sodium bicarbonate solution, extracted with ethyl acetate. The organic layer is washed with saturated saline, dried over anhydrous magnesium sulfate, concentrated to obtain 0.547 g of 4-benzyloxy-3-hydroxypyridine.

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. washThe organic layer is washed with saturated saline
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-331f82de50ac43bbaaf12280a2691e1b
Quelldatensatz
uspto-grants-2003_03
Patentnummer
US06537948B1

Notizen zur Reaktion

Wird geladen…