Hydrochloric Acid → HCID 131723149, Verbindung

HRID 1862712Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1862712
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[N:18]([CH2:19][CH3:20])[N:17]=[C:16]([CH2:21][CH3:22])[C:15]=2[CH3:23])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>CO>[ClH:24].[ClH:24].[CH2:19]([N:18]1[C:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[C:15]([CH3:23])[C:16]([CH2:21][CH3:22])=[N:17]1)[CH3:20]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 21912727HCID 21912727, Verbindung

Produkt 1

HCID 131723149HCID 131723149, VerbindungAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 1-(t-butoxycarbonyl)-4-(1,3-diethyl-4-methyl-(1H)-pyrazol-5-yl)piperidine (348 mg) (from Step E) in 2.5 N HCl in methanol was stirred at rt for 16 h. The solution was concentrated and the resulting solid was suspended in ethyl acetate, filtered and dried to afford 293 mg (92%) of the title compound.

Aufarbeitung

  1. concentrationThe solution was concentrated
  2. filtrationfiltered
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-3936394c7454453fa5734d1167b731a0
Quelldatensatz
uspto-grants-2003_03
Patentnummer
US06538002B1

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