Dimethylcarbamoyl Chloride → Carbamic acid, dimethyl-, 2,6-dimethyl-4-pyridinyl ester

HRID 1863210

Reaktionsgleichung

Reaktionsgleichung von HRID 1863210
[CH3:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[C:4]([CH3:9])[N:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:16][N:17]([CH3:21])[C:18](Cl)=[O:19]>C(#N)C>[CH3:1][C:2]1[CH:7]=[C:6]([O:8][C:18]([N:17]([CH3:21])[CH3:16])=[O:19])[CH:5]=[C:4]([CH3:9])[N:3]=1

Komponenten

5

Edukt 3

HCID 6598Dimethylcarbamoyl ChlorideHCID 11430Potassium CarbonateHCID 178429033HCID 178429033, Verbindung

Produkt 1

HCID 19112Carbamic acid, dimethyl-, 2,6-dimethyl-4-pyridinyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

30,8 g (0,25 mole) of 2,6-dimethyl-4-hydroxypyridine were suspended in 500 ml of acetonitrile, 69 g (0,5 mole) of potassium carbonate were added and the mixture was heated to reflux temperature for 2 hours. Subsequently 47 g (0,44 mole) of dimethylcarbamic acid chloride were added at an interior temperature of approximately 60°-70° C. and the mixture was maintained for two hours at about 80° C.

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureto reflux temperature for 2 hours

Quellen und Nachweise

ORD-Eintrag
ord-0d7f368c27a0473eb24cf27cb4e322ef
Quelldatensatz
uspto-grants-1979_09
Patentnummer
US04168311

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