[4-(4-Nitrophenoxy)phenyl]acetic acid → HCID 20392568, Verbindung

HRID 1863265Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1863265
[N+:1]([C:4]1[CH:20]=[CH:19][C:7]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][C:16]([OH:18])=[O:17])=[CH:11][CH:10]=2)=[CH:6][CH:5]=1)([O-])=O>C(O)C.[Pt]=O>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][C:16]([OH:18])=[O:17])=[CH:11][CH:10]=2)=[CH:19][CH:20]=1

Komponenten

4

Edukt 1

HCID 10858649[4-(4-Nitrophenoxy)phenyl]acetic acid

Produkt 1

HCID 20392568HCID 20392568, VerbindungAusbeute 40,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 82844Platinum oxide (PtO)KatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 13.65 g of [p-(p-nitrophenoxy)phenyl]acetic acid in 100 ml of ethanol is added 130 mg of platinum oxide. The mixture is shaken under 45 lb hydrogen pressure in a Parr shaker. After 2 hours, a thick white solid precipitates. The mixture is filtered, and 200 mg of fresh platinum oxide is added to the filtrate which is subjected to the reducing conditions. After an additional hour, the mixture is filtered and washed with cold ethanol. The combined solids are dissolved in hot methanol and filtered. Water is added to the filtrate to afford 4.9 g of a brown solid. A portion is recrystallized from methanol to yield the product as cream colored crystals, mp 172° C. (dec.).

Aufarbeitung

  1. customa thick white solid precipitates
  2. filtrationThe mixture is filtered
  3. addition200 mg of fresh platinum oxide is added to the filtrate which
  4. waitAfter an additional hour
  5. filtrationthe mixture is filtered
  6. washwashed with cold ethanol
  7. dissolutionThe combined solids are dissolved in hot methanol
  8. filtrationfiltered
  9. additionWater is added to the filtrate

Quellen und Nachweise

ORD-Eintrag
ord-56fe100e97ed4591ac844901abce88d9
Quelldatensatz
uspto-grants-1979_09
Patentnummer
US04168385

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