Thionyl Chloride → 6,7-Dimethoxy-2-naphthoyl chloride

HRID 1863475

Reaktionsgleichung

Reaktionsgleichung von HRID 1863475
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[CH:9]=[C:8]([C:15]([OH:17])=O)[CH:7]=[CH:6]2.S(Cl)([Cl:20])=O>CN(C)C=O.C1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[CH:9]=[C:8]([C:15]([Cl:20])=[O:17])[CH:7]=[CH:6]2

Komponenten

5

Edukt 2

HCID 24386Thionyl ChlorideHCID 2830286,7-Dimethoxy-2-naphthoic acid

Produkt 1

HCID 218249396,7-Dimethoxy-2-naphthoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 241BenzeneLösungsmittel

Versuchsvorschrift

To a solution containing 15.0 g. of 6,7-dimethoxy-2-naphthoic acid and one drop of dimethylformamide in 200 ml. of benzene was added 25 ml. of thionyl chloride. After heating one hour under reflux the mixture was evaporated to dryness in vacuo. Additional benzene was added and evaporation repeated to give 6,7-dimethoxy-2-naphthoyl chloride which was used directly in the preparation of 6,7-dimethoxy-2-naphthamide as described hereinabove in Example 113.

Aufarbeitung

  1. additionTo a solution containing 15.0 g
  2. temperatureAfter heating one hour
  3. temperatureunder reflux the mixture
  4. customwas evaporated to dryness in vacuo
  5. additionAdditional benzene was added
  6. customevaporation

Quellen und Nachweise

ORD-Eintrag
ord-4501dfb1c86a418b9cade2b8f6690a3d
Quelldatensatz
uspto-grants-1979_09
Patentnummer
US04169108

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