Hydrochloric Acid → HCID 87483712, Verbindung

HRID 1863952Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1863952
C(OC(=O)[NH:7][C@H:8]([CH2:27][C:28]1[CH:33]=[C:32]([F:34])[C:31]([F:35])=[CH:30][C:29]=1[F:36])[CH2:9][C:10]1[N:14]2[CH2:15][CH2:16][C:17]3[C:18](=[N:19][C:20]([C:23]([F:26])([F:25])[F:24])=[N:21][CH:22]=3)[C:13]2=[N:12][N:11]=1)(C)(C)C.[ClH:38]>O1CCOCC1>[ClH:38].[F:36][C:29]1[CH:30]=[C:31]([F:35])[C:32]([F:34])=[CH:33][C:28]=1[CH2:27][C@@H:8]([NH2:7])[CH2:9][C:10]1[N:14]2[CH2:15][CH2:16][C:17]3[C:18](=[N:19][C:20]([C:23]([F:24])([F:26])[F:25])=[N:21][CH:22]=3)[C:13]2=[N:12][N:11]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 90695481HCID 90695481, Verbindung

Produkt 1

HCID 87483712HCID 87483712, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To 47 mg (0.89 mmol) of tert-butyl{(1R)-1-(2,4,5-trifluorobenzyl)-2-[9-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4′,3′:1,2]pyrido[3,4-d]pyrimidin-3-yl]ethyl}carbamate was added 1.8 mL of 4M HCl in anhydrous dioxane. The mixture was stirred at room temperature for 30 minutes and then concentrated. The residue was washed with diethyl ether and dried to give the title compound as a white solid. LC-MS 429 (M+1).

Aufarbeitung

  1. concentrationconcentrated
  2. washThe residue was washed with diethyl ether
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-e1d287dcad2146fb94e045a132434b34
Quelldatensatz
uspto-grants-2009_12
Patentnummer
US07625888B2

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