Hydrochloric Acid → HCID 86614848, Verbindung

HRID 1863955Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1863955
[F:1][C:2]1[CH:27]=[C:26]([F:28])[C:25]([F:29])=[CH:24][C:3]=1[CH2:4][C@@H:5]([NH2:23])[CH2:6][C:7]1[N:15]2[C:10]([C:11]3[N:12]([N:16]=[C:17]([C:19]([F:22])([F:21])[F:20])[N:18]=3)[CH2:13][CH2:14]2)=[N:9][N:8]=1.[ClH:30]>O1CCOCC1>[ClH:30].[F:1][C:2]1[CH:27]=[C:26]([F:28])[C:25]([F:29])=[CH:24][C:3]=1[CH2:4][C@@H:5]([NH2:23])[CH2:6][C:7]1[N:15]2[C:10]([C:11]3[N:12]([N:16]=[C:17]([C:19]([F:22])([F:21])[F:20])[N:18]=3)[CH2:13][CH2:14]2)=[N:9][N:8]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 11589768HCID 11589768, Verbindung

Produkt 1

HCID 86614848HCID 86614848, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

The {(1R)-1-(2,4,5-trifluorobenzyl)-2-[9-(trifluoromethyl)-5,6-dihydrobis[1,2,4]triazolo[1,5-a:3′,4′-c]pyrazin-3-yl]ethyl}amine (free base) from Step A was treated an excess of 4M HCl in anhydrous dioxane, and the mixture was stirred at room temperature for 1 h. The residue obtained upon concentration of the reaction mixture was washed with ether and dried to afford the title compound as a white solid. LC-MS 418 (M+1).

Aufarbeitung

  1. customThe residue obtained upon concentration of the reaction mixture
  2. washwas washed with ether
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-ab51c4899b594c628c045e5568372ed2
Quelldatensatz
uspto-grants-2009_12
Patentnummer
US07625888B2

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