4-Chloro-2-trifluoromethylpyrazolo[1.5-a]pyrazine → HCID 131727793, Verbindung

HRID 1863968Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1863968
[C:1]([O:5][C:6](=[O:24])[NH:7][C@H:8]([CH2:14][C:15]1[CH:20]=[C:19]([F:21])[C:18]([F:22])=[CH:17][C:16]=1[F:23])[CH2:9][C:10]([NH:12][NH2:13])=O)([CH3:4])([CH3:3])[CH3:2].Cl[C:26]1[C:27]2[N:28]([N:32]=[C:33]([C:35]([F:38])([F:37])[F:36])[CH:34]=2)[CH:29]=[CH:30][N:31]=1>>[C:1]([O:5][C:6](=[O:24])[NH:7][C@H:8]([CH2:14][C:15]1[CH:20]=[C:19]([F:21])[C:18]([F:22])=[CH:17][C:16]=1[F:23])[CH2:9][C:10]1[N:31]2[C:26]([C:27]3[N:28]([N:32]=[C:33]([C:35]([F:38])([F:36])[F:37])[CH:34]=3)[CH:29]=[CH:30]2)=[N:13][N:12]=1)([CH3:4])([CH3:3])[CH3:2]

Komponenten

3

Edukt 2

HCID 579737724-Chloro-2-trifluoromethylpyrazolo[1.5-a]pyrazine2×HCID 57973796HCID 57973796, Verbindung2×

Produkt 1

HCID 131727793HCID 131727793, Verbindung

Versuchsvorschrift

A mixture of 7.7 mg (0.22 mmol) of tert-butyl[(1R)-3-hydrazino-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamate (Intermediate 4), 4.9 mg (0.22 mmol) of 4-chloro-2-(trifluoromethyl)pyrazolo[1,5-a]pyrazine (Intermediate 39), and 0.5 mL of xylenes was stirred at reflux for 19 h. The cooled solution was concentrated to yield the title compound, sufficiently pure for use in the next step. LC-MS 515 (M+1).

Aufarbeitung

  1. temperatureat reflux for 19 h
  2. concentrationThe cooled solution was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-d5798a9a36ef485a85a8301247a78eaf
Quelldatensatz
uspto-grants-2009_12
Patentnummer
US07625888B2

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