Ammonia → 6-Morpholinopyridine-3-sulfonamide

HRID 1863984Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1863984
[N:1]1([C:7]2[N:12]=[CH:11][C:10]([S:13](Cl)(=[O:15])=[O:14])=[CH:9][CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[NH3:17]>O1CCOCC1>[N:1]1([C:7]2[N:12]=[CH:11][C:10]([S:13]([NH2:17])(=[O:15])=[O:14])=[CH:9][CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 27764626-Morpholin-4-yl-pyridine-3-sulfonyl chloride

Produkt 1

HCID 573002496-Morpholinopyridine-3-sulfonamideAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

6-Morpholin-4-yl-pyridine-3-sulfonyl chloride (1.25 g, 4.8 mmol) was dissolved in a 0.5M solution of ammonia in dioxane (20 mL) and the mixture stirred for 16 hours at room temperature. The mixture was filtered and concentrated in vacuo to afford 6-morpholin-4-yl-pyridine-3-sulfonic acid amide as a white solid 1.1 g (96% yield).

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-9d78d929518d4946b55629e785705b2b
Quelldatensatz
uspto-grants-2009_12
Patentnummer
US07625896B2

Notizen zur Reaktion

Wird geladen…