Hydrochloric Acid → (RS)-1-(3-methoxy-benzenesulfonyl)-2-oxo-3-phenyl-imidazolidine-4-carboxylic acid

HRID 1864362

Reaktionsgleichung

Reaktionsgleichung von HRID 1864362
C[O:2][C:3]([CH:5]1[CH2:9][N:8]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[CH:14]=2)(=[O:12])=[O:11])[C:7](=[O:21])[N:6]1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:4].[OH-].[Na+].Cl>O1CCCC1.CO>[CH3:20][O:19][C:15]1[CH:14]=[C:13]([S:10]([N:8]2[CH2:9][CH:5]([C:3]([OH:4])=[O:2])[N:6]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:7]2=[O:21])(=[O:11])=[O:12])[CH:18]=[CH:17][CH:16]=1

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67141140(RS)-1-(3-methoxy-benzenesulfonyl)-2-oxo-3-phenyl-imidazolidine-4-carboxylic acid methyl ester

Produkt 1

HCID 67141122(RS)-1-(3-methoxy-benzenesulfonyl)-2-oxo-3-phenyl-imidazolidine-4-carboxylic acidAusbeute 96,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To a solution of (RS)-1-(3-methoxy-benzenesulfonyl)-2-oxo-3-phenyl-imidazolidine-4-carboxylic acid methyl ester (0.043 g) in tetrahydrofuran (0.5 ml) and methanol (0.5 ml) was added a 1 M aqueous NaOH solution (0.13 ml) at 0° C. The mixture was stirred at 0° C. for 30 min. 1 M HCl (0.15 ml) was added and the organic solvents were evaporated. The colorless precipitate was collected by filtration, washed with water and dried to give (RS)-1-(3-methoxy-benzenesulfonyl)-2-oxo-3-phenyl-imidazolidine-4-carboxylic acid (0.040 g) as a colorless solid.

Aufarbeitung

  1. customthe organic solvents were evaporated
  2. filtrationThe colorless precipitate was collected by filtration
  3. washwashed with water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-d1e9784ae0b14095bfa17a412feeaf2d
Quelldatensatz
uspto-grants-2009_12
Patentnummer
US07625902B2

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