Trifluoroacetic acid → HCID 68592998, Verbindung

HRID 1864490Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1864490
[OH:1][C@H:2]1[CH2:6][N:5](C(OC(C)(C)C)=O)[C@@H:4]([CH2:14][OH:15])[CH2:3]1.[C:16]([OH:22])([C:18]([F:21])([F:20])[F:19])=[O:17]>C(Cl)Cl>[F:19][C:18]([F:21])([F:20])[C:16]([OH:22])=[O:17].[OH:15][CH2:14][C@@H:4]1[NH:5][CH2:6][C@H:2]([OH:1])[CH2:3]1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 10680283tert-Butyl (2R,4R)-4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate

Produkt 1

HCID 68592998HCID 68592998, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

1,1-Dimethylethyl(2R,4R)-4-hydroxy-2-(hydroxymethyl)-1-pyrrolidinecarboxylate (0.185 g, 0.852 mmol) was stirred in a 1:1 solution of methylene chloride:TFA for 14 hours. The reaction was concentrated, and the crude material was used without further purification. 1H NMR (400 MHz, DMSO-D6) δ ppm 1.5 (m, 1H), 2.2 (m, 4H), 3.0 (m, 1H), 3.1 (m, 1H), 3.6 (m, 3H), 4.3 (m, 1H), 5.3 (s, br, 2H), 8.6 (s, br, 1H), 9.2 (s, br, 1H).

Aufarbeitung

  1. concentrationThe reaction was concentrated
  2. customthe crude material was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-c024fe85139b458b96c0a4a5bd415756
Quelldatensatz
uspto-grants-2009_12
Patentnummer
US07625909B2

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