tert-butyl (2R,3S)-3-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate → 2-Pyrrolidinemethanol, 3-hydroxy-, hydrochloride, (2R,3S)-

HRID 1864509Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1864509
[OH:1][C@H:2]1[CH2:6][CH2:5][N:4](C(OC(C)(C)C)=O)[C@@H:3]1[CH2:14][OH:15].[ClH:16].C[C@H]1CCN[C@@H]1CO>>[ClH:16].[OH:15][CH2:14][C@@H:3]1[C@@H:2]([OH:1])[CH2:6][CH2:5][NH:4]1

Komponenten

3

Edukt 2

HCID 10910976tert-butyl (2R,3S)-3-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylateHCID 57463460HCID 57463460, Verbindung

Produkt 1

HCID 156073442-Pyrrolidinemethanol, 3-hydroxy-, hydrochloride, (2R,3S)-

Versuchsvorschrift

The title compound was prepared from 1,1-dimethylethyl (2R, 3S)-3-hydroxy-2-(hydroxymethyl)-1-pyrrolidinecarboxylate using the methods used to prepare [(2S,3S)-3-methyl-2-pyrrolidinyl]methanol hydrochloride. 1H NMR (400 MHz, DMSO-D6) δ ppm 1.8 (m, 1H), 2.0 (m, 1H), 2.5 (m, 2H), 3.2 (m, 2H), 3.3 (m, 1H), 3.5 (m, 1H), 3.6 (m, 1H), 4.1 (m, 1H), 8.7 (s, 1H), 9.5 (m, 1H). ES+=117.97.

Quellen und Nachweise

ORD-Eintrag
ord-6b703e435b54497e97a421a205593baa
Quelldatensatz
uspto-grants-2009_12
Patentnummer
US07625909B2

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