(6-Iodopyridin-3-yl)methanol → 6-Iodopyridine-3-carbaldehyde

HRID 1864572Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1864572
[I:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][OH:9])=[CH:4][CH:3]=1>ClCCl.[O-2].[O-2].[Mn+4]>[I:1][C:2]1[N:7]=[CH:6][C:5]([CH:8]=[O:9])=[CH:4][CH:3]=1

Komponenten

4

Edukt 1

HCID 23039516(6-Iodopyridin-3-yl)methanol

Produkt 1

HCID 534852236-Iodopyridine-3-carbaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

63 g (723 mmol) of manganese dioxide are added to a solution of 17 g (72 mmol) of (6-iodopyrid-3-yl)methanol in 600 ml of dichloromethane. The reaction medium is stirred at room temperature for 20 hours and then filtered through Celite. The precipitate is washed thoroughly with water and the filtrate is evaporated under vacuum. The residue obtained is taken up in dichloromethane and the insoluble material is again filtered off. After evaporation of the filtrate, 13.2 g (78%) of 6-iodopyridine-3-carbaldehyde are obtained in the form of a pale yellow solid with a melting point of 141° C.

Aufarbeitung

  1. filtrationfiltered through Celite
  2. washThe precipitate is washed thoroughly with water
  3. customthe filtrate is evaporated under vacuum
  4. customThe residue obtained
  5. filtrationthe insoluble material is again filtered off
  6. customAfter evaporation of the filtrate, 13.2 g (78%) of 6-iodopyridine-3-carbaldehyde
  7. customare obtained in the form of a pale yellow solid with a melting point of 141° C.

Quellen und Nachweise

ORD-Eintrag
ord-fcd6b61a62354943b0685c981a0713b1
Quelldatensatz
uspto-grants-2009_12
Patentnummer
US07625914B2

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