Sulfanilamide → 4-[2-(2,4-Dichloro-phenyl)-5-methyl-pyrrol-1-yl]-benzenesulfonamide

HRID 18646

Reaktionsgleichung

Reaktionsgleichung von HRID 18646
[Cl:1][C:2]1[CH:9]=[C:8]([Cl:10])[CH:7]=[CH:6][C:3]=1[CH:4]=O.[CH3:11][C:12](=O)[CH:13]=[CH2:14].[NH2:16][S:17]([C:20]1[CH:25]=[CH:24][C:23]([NH2:26])=[CH:22][CH:21]=1)(=[O:19])=[O:18]>>[Cl:1][C:2]1[CH:9]=[C:8]([Cl:10])[CH:7]=[CH:6][C:3]=1[C:4]1[N:26]([C:23]2[CH:24]=[CH:25][C:20]([S:17]([NH2:16])(=[O:18])=[O:19])=[CH:21][CH:22]=2)[C:12]([CH3:11])=[CH:13][CH:14]=1

Komponenten

4

Edukt 3

HCID 5333SulfanilamideHCID 6570Methyl vinyl ketoneHCID 134042,4-Dichlorobenzaldehyde

Produkt 1

HCID 684844054-[2-(2,4-Dichloro-phenyl)-5-methyl-pyrrol-1-yl]-benzenesulfonamide

Versuchsvorschrift

2,4-Dichlorobenzaldehyde and but-3-en-2-one were treated according to the procedure outlined in General Procedure C followed by subjecting the resulting product to conditions outlined in General Procedure D along with p-aminosulfonyl phenylamine to obtain the titled compound. 1H NMR (CDCl3) δ ppm 2.20 (3H), 4.82 (2H), 6.12 (1H), 6.35 (1H), 7.15-7.90 (8H); MS (ESI) m/z 381/383.

Quellen und Nachweise

ORD-Eintrag
ord-bde0fa61e3344be3b7d0a8e1b78079c1
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741364B2

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