HCID 66865136, Verbindung → HCID 57974031, Verbindung
Reaktionsgleichung
FC1C=C([C@@H]2CCCC(=O)N2[C:16]([O:18]C(C)(C)C)=[O:17])C=C(F)C=1.[F:23][C:24]1[CH:25]=[C:26]([C@H:31]2[N:36]([C:37](OC(C)(C)C)=O)[C:35](=[O:44])[C@H:34]([CH3:45])[CH2:33][CH2:32]2)[CH:27]=[C:28]([F:30])[CH:29]=1>>[F:30][C:28]1[CH:27]=[C:26]([C@H:31]2[N:36]([CH2:37][C:16]([OH:18])=[O:17])[C:35](=[O:44])[C@H:34]([CH3:45])[CH2:33][CH2:32]2)[CH:25]=[C:24]([F:23])[CH:29]=1Komponenten
3
Versuchsvorschrift
Essentially following the procedures described for Intermediate 26, but using tert-butyl (3R,6S)-6-(3,5-difluorophenyl)-3-methylpiperidin-2-one-1-carboxylate in place of tert-butyl (6S)-6-(3,5-difluorophenyl)-3,3-diethylpiperidin-2-one-1-carboxylate, the title compound was prepared. MS: m/z=284 (M+1).
Quellen und Nachweise
- ORD-Eintrag
- ord-c51e95f32fa647a7b73ee54621608f34
- Quelldatensatz
- uspto-grants-2009_12