HCID 22278860, Verbindung → 4-Dimethylamino-3-ethyl-3-methylpiperidine

HRID 1865263Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1865263
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:16])[CH3:15])[C:10]([CH2:18][CH3:19])([CH3:17])[CH2:9]1)C1C=CC=CC=1>CO.[H][H].[OH-].[OH-].[Pd+2]>[CH3:15][N:14]([CH3:16])[CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][C:10]1([CH2:18][CH3:19])[CH3:17]

Komponenten

5

Edukt 1

HCID 22278860HCID 22278860, Verbindung

Produkt 1

HCID 222788404-Dimethylamino-3-ethyl-3-methylpiperidine

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 9942167Palladium hydroxideKatalysatorHCID 887MethanolLösungsmittelHCID 178418361HCID 178418361, VerbindungLösungsmittel

Versuchsvorschrift

A mixture of 20% Pd(OH)2 on carbon (0.7 g) and 1-benzyl-4-dimethylamino-3-ethyl-3-methyl piperidine (6 g, 23 mmol) in methanol (50 ml) was stirred in hydrogen atmosphere (1 atm.) for 48 hr at room temperature. The catalyst was filtered off, washed with methanol and filtrate was concentrated to afford 4-dimethylamino-3-ethyl-3-methylpiperidine. Yield 2.8 g (72%), C10H22N2, m/z 171 (M+1).

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. washwashed with methanol and filtrate
  3. concentrationwas concentrated

Quellen und Nachweise

ORD-Eintrag
ord-4b84e645a5854a6282e9f8d096d870d0
Quelldatensatz
uspto-grants-2009_12
Patentnummer
US07626032B2

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