Tetrahydrofuran → {3-[3-(2-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-phenyl}-acetic acid

To a mixture of 3-(2-Methoxy-phenyl)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-b]pyridine (500 mg, 1.04 mmol) and 3-bromophenylacetic acid (268 mg, 1.25 mmol) in a 20 mL microwave reaction flask was added THF (3 mL), acetonitrile (3 mL) and sodium carbonate (3 mL, 1 N aqueous solution, 3 mmol). The mixture was bubbled with N2 for 1 min. dichloro[1,1′-bis(diphenylphoshino)ferrocene]palladium(II) (73 mg, 10% mol) was added and the bubbling continued for another minute. The flask was sealed and irradiated with microwave in Emrys Optimizer at 120° C. for 20 min. The reaction mixture was partitioned between aqueous saturated sodium chloride and ethyl acetate (15 mL: 15 mL). The aqueous layer was extracted with ethyl acetate (10 mL×2). Normal work up of the combined organic layers and purification with flash chromatography on silsca gel using a gradient of methanol in dichloromethane yielded {3-[3-(2-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-phenyl}-acetic acid as a yellow solid (340 mg, 67% yield). MS: m/z 490 (M+H+).

1. customin a 20 mL microwave reaction flask
2. customThe mixture was bubbled with N2 for 1 min. dichloro[1,1′-bis(diphenylphoshino)ferrocene]palladium(II) (73 mg, 10% mol)
3. additionwas added
4. customThe flask was sealed
5. customirradiated with microwave in Emrys Optimizer at 120° C. for 20 min
6. customThe reaction mixture was partitioned between aqueous saturated sodium chloride and ethyl acetate (15 mL: 15 mL)
7. extractionThe aqueous layer was extracted with ethyl acetate (10 mL×2)
8. customNormal work up of the combined organic layers and purification with flash chromatography on silsca gel

ORD-Eintrag

ord-791c1a1b459f41aba842172c92d77a35

Quelldatensatz

uspto-grants-2009_12

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07626021B2