HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Fluoro-4-morpholinoaniline → (2R)-1-Chloro-3-[[3-fluoro-4-(4-morpholinyl)phenyl]amino]-2-propanol
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Fluoro-4-morpholinoaniline | HCID 1485330 | — |
| Edukt | (-)-Epichlorohydrin | HCID 2734062 | — |
| Lösungsmittel | Isopropanol | HCID 3776 | — |
| Produkt | (2R)-1-Chloro-3-[[3-fluoro-4-(4-morpholinyl)phenyl]amino]-2-propanol | HCID 16655948 | 99,3% |
Reaktionsschritte
3-Fluoro-4-morpholinyl aniline (39 g) is mixed with R-epichlorohydrin (18.5 g), isopropyl alcohol (200 ml) is added and heated for 16 hours at reflux temperature. The solvent is distilled to give 57 gm of N-[3-Chloro-2-(R)-hydroxypropyl]-3-fluoro-4-morpholinyl aniline.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07741480B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-be059e33dcdc4ec49c1e9eb1e2a24b02 |
| Quellennotiz | uspto-grants-2010_06 |