Cinnamic Acid → 1-[(e)-(3-Phenyl-acryloyl)]-4-(3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one

HRID 1867424Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1867424
Cl.Cl.[N:3]1([CH2:9][CH2:10][CH2:11][N:12]2[C:18](=[O:19])[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.[C:20](O)(=[O:29])/[CH:21]=[CH:22]/[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[C:23]1(/[CH:22]=[CH:21]/[C:20]([N:15]2[CH2:16][CH2:17][C:18](=[O:19])[N:12]([CH2:11][CH2:10][CH2:9][N:3]3[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]3)[CH2:13][CH2:14]2)=[O:29])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Komponenten

3

Edukt 2

HCID 444539Cinnamic AcidHCID 670807474-(3-Piperidin-1-yl-propyl)-[1,4]diazepan-5-one dihydrochloride2×

Produkt 1

HCID 684321091-[(e)-(3-Phenyl-acryloyl)]-4-(3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one

Versuchsvorschrift

In analogy to the procedure described in example 11A, 4-(3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one-dihydrochloride (intermediate 4B) and (E)-cinnamic acid gave the title compound as off-white solid. MS: 370.2 (MH+).

Quellen und Nachweise

ORD-Eintrag
ord-edd0a46ba3b84c42966fd2d2171248f1
Quelldatensatz
uspto-grants-2009_12
Patentnummer
US07632829B2

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