Trifluoroacetic acid → Trifluoroacetic acid

HRID 1867579Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1867579
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C(OC([N:15]1[CH2:20][CH2:19][CH:18]([N:21]2[CH2:25][CH2:24][NH:23][C:22]2=[O:26])[CH2:17][CH2:16]1)=O)(C)(C)C>ClCCl>[NH:15]1[CH2:16][CH2:17][CH:18]([N:21]2[CH2:25][CH2:24][CH2:2][NH:23][C:22]2=[O:26])[CH2:19][CH2:20]1.[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4]

Komponenten

5

Edukt 2

HCID 6422Trifluoroacetic acidHCID 46344059Tert-butyl 4-(2-oxoimidazolidin-1-yl)piperidine-1-carboxylate

Produkt 2

HCID 6422Trifluoroacetic acidHCID 155726661-(Piperidin-4-yl)-1,3-diazinan-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Trifluoroacetic acid (0.5 mL) was added to a solution of 1-(1-t-butoxycarbonylpiperidin-4-yl)imidazolidin-2-one (20 mg, 0.07 mmol) in dichloromethane (2 mL) and the reaction stirred at room temperature overnight. The reaction was concentrated in vacuo to give the title compound as its trifluoroacetic acid salt (12 mg).

Aufarbeitung

  1. concentrationThe reaction was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-5b9695d05f5d46c5aa4c11c558682937
Quelldatensatz
uspto-grants-2009_12
Patentnummer
US07632832B2

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