HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1,1-Dichloroethane → 1-(3-Chloropyridin-2-yl)piperazine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1,1-Dichloroethane | HCID 6365 | — |
| Edukt | Trifluoroacetic acid | HCID 6422 | — |
| Edukt | Tert-butyl 4-(3-chloropyridin-2-yl)piperazine-1-carboxylate | HCID 11630777 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | 1-(3-Chloropyridin-2-yl)piperazine | HCID 11412944 | — |
Reaktionsschritte
To a clear solution of tert-butyl 4-(3-chloropyridin-2-yl)piperazine-1-carboxylate in anhydrous dichloromethane (25 mL) was added TFA (25 mL) dropwise. The yellow solution was stirred at room temperature for 2.5 hour. Reaction was complete as determined by TLC. TFA was azeotropped with dichloroethane to give 1-(3-chloropyridin-2-yl)piperazine in quantitative yield (1.265 g).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07632838B2 |
| Quelldatensatz | uspto-grants-2009_12 |
| ORD ID | ord-30b29d4f567642f38fcd9d67ddf87c72 |
| Quellennotiz | uspto-grants-2009_12 |