Potassium Carbonate → (2-Methyl-imidazol-1-yl)-acetic acid methyl ester

HRID 18689

Reaktionsgleichung

Reaktionsgleichung von HRID 18689
[CH3:1][O:2][C:3](=[O:6])[CH2:4]Br.[CH3:7][C:8]1[NH:9][CH:10]=[CH:11][N:12]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH3:1][O:2][C:3](=[O:6])[CH2:4][N:9]1[CH:10]=[CH:11][N:12]=[C:8]1[CH3:7]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 127492-MethylimidazoleHCID 60984Methyl bromoacetate

Produkt 1

HCID 28940036(2-Methyl-imidazol-1-yl)-acetic acid methyl esterAusbeute 47 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

4 ml of bromo acetic acid methyl ester is dissolved in 30 ml DMF and 5.2 g of 2-methylimidazole and 11.2 g potassium carbonate are added. The reaction mixture is stirred at room temperature for several hours and then subjected to aqueous work up. After removal of the solvent the pure product is obtained by flash chromatography in 47 to 78% yield.

Aufarbeitung

  1. customAfter removal of the solvent the pure product
  2. customis obtained by flash chromatography in 47 to 78% yield

Quellen und Nachweise

ORD-Eintrag
ord-0bedc00b6d0b4bcbacdd64180013cb6f
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741488B2

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