Ethanolamine → 2-[2-Benzyloxycarbonylamino-2-(methyl)propionylamino]ethanol

HRID 1868999Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1868999
[CH2:1]([O:8][C:9]([NH:11][C:12]([CH3:17])([CH3:16])[C:13]([OH:15])=O)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N1C=CN=C1)(N1C=CN=C1)=O.[NH2:30][CH2:31][CH2:32][OH:33]>O1CCCC1>[CH2:1]([O:8][C:9]([NH:11][C:12]([CH3:17])([CH3:16])[C:13]([NH:30][CH2:31][CH2:32][OH:33])=[O:15])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 700EthanolamineHCID 682631,1'-CarbonyldiimidazoleHCID 294936N-((Benzyloxy)carbonyl)-2-methylalanine

Produkt 1

HCID 689478742-[2-Benzyloxycarbonylamino-2-(methyl)propionylamino]ethanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 2-benzyloxycarbonylamino-2-(methyl)-propionic acid (1 g) in tetrahydrofuran (5 mL) was added 1,1′-carbonylbis-1H-imidazole (889 mg), and the mixture was stirred at room temperature for 1 hour. To the reaction mixture was added 2-aminoethanol (0.38 mL), and the mixture was stirred at room temperature for 2 hours. The reaction mixture was purified by column chromatography on silica gel (eluent: dichloromethane/methanol=20/1) to give 2-[2-benzyloxycarbonylamino-2-(methyl)propionylamino]ethanol (973 mg).

Aufarbeitung

  1. stirringthe mixture was stirred at room temperature for 2 hours
  2. customThe reaction mixture was purified by column chromatography on silica gel (eluent: dichloromethane/methanol=20/1)

Quellen und Nachweise

ORD-Eintrag
ord-40d78c11d42047a997c23841cfa4fadf
Quelldatensatz
uspto-grants-2009_12
Patentnummer
US07635684B2

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