Benzimidazole → HCID 178495389, Verbindung

HRID 1869609Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1869609
[CH3:1][C:2]1[C:7]([CH2:8][S+:9]([O-:19])[C:10]2[NH:11][C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:17]=3[N:18]=2)=[N:6][CH:5]=[CH:4][C:3]=1[O:20][CH2:21][CH2:22][CH2:23][O:24][CH3:25].N1C2C=CC=CC=2NC=1.[OH-].[Na+:36]>C(OC(=O)C)C.N>[CH3:1][C:2]1[C:7]([CH2:8][S+:9]([O-:19])[C:10]2[NH:11][C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:17]=3[N:18]=2)=[N:6][CH:5]=[CH:4][C:3]=1[O:20][CH2:21][CH2:22][CH2:23][O:24][CH3:25].[CH3:1][C:2]1[C:7]([CH2:8][S+:9]([O-:19])[C:10]2[N-:11][C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:17]=3[N:18]=2)=[N:6][CH:5]=[CH:4][C:3]=1[O:20][CH2:21][CH2:22][CH2:23][O:24][CH3:25].[Na+:36]

Komponenten

7

Edukt 3

HCID 5798BenzimidazoleHCID 14798Sodium HydroxideHCID 178495390HCID 178495390, Verbindung2×

Produkt 2

HCID 178495389HCID 178495389, VerbindungHCID 178495390HCID 178495390, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 222AmmoniaLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

PCT Application PCT/GB2004/000064 and International Publication Number WO 2004/063188 A1, discloses the preparation of rabeprazole and benzimidazole type of compounds. Accordingly, rabeprazole base is prepared by oxidation using sodium hypohalites and isolated. Rabeprazole sodium is prepared by dissolving rabeprazole base in ethylacetate and methanolic ammonia mixture to which methanolic sodium hydroxide is added. The solvent is distilled and rabeprazole sodium is isolated from ethylacetate and n-heptane/n-hexane mixture.

Aufarbeitung

  1. customisolated
  2. customRabeprazole sodium is prepared
  3. additionis added
  4. distillationThe solvent is distilled

Quellen und Nachweise

ORD-Eintrag
ord-01389cdce6cb4e38ac51b1c46ea960b8
Quelldatensatz
uspto-grants-2009_12
Patentnummer
US07638633B2

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