1,1-Dimethylethyl 4-[(1-ethyl-4-piperidinyl)methyl]-1-piperidinecarboxylate → 1-Ethyl-4-(piperidin-4-ylmethyl)piperidine

HRID 1869626Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1869626
[CH2:1]([N:3]1[CH2:8][CH2:7][CH:6]([CH2:9][CH:10]2[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]2)[CH2:5][CH2:4]1)[CH3:2]>Cl.O1CCOCC1>[CH2:1]([N:3]1[CH2:4][CH2:5][CH:6]([CH2:9][CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH2:7][CH2:8]1)[CH3:2]

Komponenten

3

Edukt 1

HCID 688869521,1-Dimethylethyl 4-[(1-ethyl-4-piperidinyl)methyl]-1-piperidinecarboxylate

Produkt 1

HCID 534072191-Ethyl-4-(piperidin-4-ylmethyl)piperidineAusbeute 87,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 204431481,4-Dioxane hydrochlorideLösungsmittel

Versuchsvorschrift

1,1-Dimethylethyl 4-[(1-ethyl-4-piperidinyl)methyl]-1-piperidinecarboxylate (may be prepared as described in Description 7) (2.5 g) was stirred in a solution of HCl-Dioxane (70 ml, 4M) for 2 h. The solvent was evaporated and the resultant hydrochloride salt was dissolved in saturated potassium carbonate (25 ml). The solution was extracted into DCM (3×50 ml) and the combined organics dried (MgSO4) and evaporated to give the title compound (D8) (1.48 g).

Aufarbeitung

  1. customThe solvent was evaporated
  2. dissolutionthe resultant hydrochloride salt was dissolved in saturated potassium carbonate (25 ml)
  3. extractionThe solution was extracted into DCM (3×50 ml)
  4. dry with materialthe combined organics dried (MgSO4)
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-5f11804044cf414b8dd5924d975cae79
Quelldatensatz
uspto-grants-2009_12
Patentnummer
US07638631B2

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