1,1-Dimethylethyl 4-{[1-(cyclopropylmethyl)-4-piperidinyl]methyl}-1-piperidinecarboxylate → 1-(Cyclopropylmethyl)-4-(4-piperidinylmethyl)piperidine

HRID 1869628Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1869628
[CH:1]1([CH2:4][N:5]2[CH2:10][CH2:9][CH:8]([CH2:11][CH:12]3[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]3)[CH2:7][CH2:6]2)[CH2:3][CH2:2]1>Cl.O1CCOCC1>[CH:1]1([CH2:4][N:5]2[CH2:10][CH2:9][CH:8]([CH2:11][CH:12]3[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]3)[CH2:7][CH2:6]2)[CH2:2][CH2:3]1

Komponenten

3

Edukt 1

HCID 688855731,1-Dimethylethyl 4-{[1-(cyclopropylmethyl)-4-piperidinyl]methyl}-1-piperidinecarboxylate

Produkt 1

HCID 688844871-(Cyclopropylmethyl)-4-(4-piperidinylmethyl)piperidineAusbeute 71,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 204431481,4-Dioxane hydrochlorideLösungsmittel

Versuchsvorschrift

1,1-Dimethylethyl 4-{[1-(cyclopropylmethyl)-4-piperidinyl]methyl}-1-piperidinecarboxylate (may be prepared as described in Description 9) (2.0 g) was stirred in a solution of HCl-Dioxane (700 ml, 4M) for 2 h. The solvent was evaporated and the resultant yellow solid was dissolved in saturated potassium carbonate (25 ml). The solution was extracted into dichloromethane (3×50 ml) and the combined organics dried (MgSO4) and evaporated to give the title compound (D10) (1.0 g).

Aufarbeitung

  1. customThe solvent was evaporated
  2. dissolutionthe resultant yellow solid was dissolved in saturated potassium carbonate (25 ml)
  3. extractionThe solution was extracted into dichloromethane (3×50 ml)
  4. dry with materialthe combined organics dried (MgSO4)
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-d559086f863143e38ba2ee3ddb87f8ba
Quelldatensatz
uspto-grants-2009_12
Patentnummer
US07638631B2

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