Norchlorcyclizine → Cetirizine methyl ester

HRID 1871009

Reaktionsgleichung

Reaktionsgleichung von HRID 1871009
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[CH:4][CH:3]=1.Cl[CH2:22][CH2:23][O:24][CH2:25][C:26]([O:28][CH3:29])=[O:27]>C(N(CC)CC)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[N:9]2[CH2:10][CH2:11][N:12]([CH2:22][CH2:23][O:24][CH2:25][C:26]([O:28][CH3:29])=[O:27])[CH2:13][CH2:14]2)=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 9340NorchlorcyclizineHCID 15337474Methyl (2-chloroethoxy)acetate

Produkt 1

HCID 608480Cetirizine methyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

10 gr. of (0.035 mole) of 1-[(4-chlorophenyl)phenylmethyl]piperazine, 8.06 gr. (0.0525 mole) of methyl 2-chloroethoxyacetate and 50 ml. of triethylamine were introduced into a pressure vessel and treated in a similar way as described in example 1. 12.5 gr. of methyl [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetate is obtained as reddish oil (88.7% yield).

Aufarbeitung

  1. additiontreated in a similar way

Quellen und Nachweise

ORD-Eintrag
ord-950f1ae5ba8a4647af578eb869f7464a
Quelldatensatz
uspto-grants-2000_08
Patentnummer
US06100400

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