Hydrochloric Acid → 3,4-bis-(3-Fluorophenyl)-1,2,5-thiadiazole-1,1-dioxide

HRID 18711

Reaktionsgleichung

Cl.[F:2][C:3]1[CH:4]=[C:5]([C:9]([C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=2)=O)=O)[CH:6]=[CH:7][CH:8]=1.[S:20]([NH2:24])([NH2:23])(=[O:22])=[O:21]>CO>[F:2][C:3]1[CH:4]=[C:5]([C:9]2[C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=3)=[N:24][S:20](=[O:22])(=[O:21])[N:23]=2)[CH:6]=[CH:7][CH:8]=1

Komponenten

Reaktionsbedingungen

Temperatur: 66 °C

Versuchsvorschrift

Hydrogen chloride is bubbled through a solution of 3,3′-difluorobenzil (20) (3.81 g, 15.7 mmol) and sulfamide (1.53 g, 15.9 mmol) in methanol (15 mL) for 0.5 min followed by heating at 66° C. for 2 h. The reaction mixture is cooled to RT, the solvent rotary evaporated, and the residue triturated from heptane to give 3.50 g of the product 21.

Aufarbeitung

temperatureThe reaction mixture is cooled to RT
customthe solvent rotary evaporated, and the residue triturated from heptane

Quellen und Nachweise

ORD-Eintrag: ord-534affd4eb524b5fbc80708d57bf766a
Quelldatensatz: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07741493B2

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