Methylamine → HCID 10643064, Verbindung

HRID 1871138Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1871138
[Cl:1][C:2]1[C:20](/[CH:21]=[CH:22]/[CH2:23][N:24]2C(=O)C3=CC=CC=C3C2=O)=[CH:19][CH:18]=[C:17]([Cl:35])[C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:15]=1[N:14]=[C:13]([CH3:16])[CH:12]=[CH:11]2.CN>C(Cl)(Cl)Cl.CO>[NH2:24][CH2:23]/[CH:22]=[CH:21]/[C:20]1[C:2]([Cl:1])=[C:3]([C:17]([Cl:35])=[CH:18][CH:19]=1)[CH2:4][O:5][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:15]=1[N:14]=[C:13]([CH3:16])[CH:12]=[CH:11]2

Komponenten

5

Edukt 2

HCID 6329MethylamineHCID 10601564HCID 10601564, Verbindung

Produkt 1

HCID 10643064HCID 10643064, VerbindungAusbeute 84,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 6212ChloroformLösungsmittel

Versuchsvorschrift

To a solution of 8-[2,6-dichloro-3-((E)-3-phthalimido-1-propenyl)benzyloxy]-2-methylquinoline (43 mg) in chloroform (1 ml) was added 2M solution of methylamine in methanol (0.5 ml), and the mixture was stirred in the dark at ambient temperature overnight. The mixture was evaporated in vacuo, and the residue was purified by preparative thin layer chromatography to give 8-[3-((E)-3-amino-1-propenyl)-2,6-dichlorobenzyloxy]-2-methylquinoline (27 mg) as pale yellow amorphous.

Aufarbeitung

  1. customThe mixture was evaporated in vacuo
  2. customthe residue was purified by preparative thin layer chromatography

Quellen und Nachweise

ORD-Eintrag
ord-0153f418855f4f93b1ab61bb02cd4328
Quelldatensatz
uspto-grants-2000_08
Patentnummer
US06100284

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