Bromocycloheptane → (cis)-4-(3,4-Dimethoxyphenyl)-2-cyclopentyl-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C@H:20]3[C@H:15]([CH2:16][CH:17]=[CH:18][CH2:19]3)[C:14](=[O:21])[NH:13][N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[CH:22]1(Br)[CH2:28][CH2:27][CH2:26][CH2:25]CC1.COC1C=C(C2[C@H]3[C@H](CCCC3)C(=O)N(C)N=2)C=CC=1OC>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C@H:20]3[C@H:15]([CH2:16][CH:17]=[CH:18][CH2:19]3)[C:14](=[O:21])[N:13]([CH:25]3[CH2:26][CH2:27][CH2:28][CH2:22]3)[N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]Komponenten
4
Edukt 3
Produkt 1
Versuchsvorschrift
Prepared from compound 3 and cycloheptylbromide as described for compound 8. Purified by chromatography (dichloromethane) and crystallized from diethyl ether. M.p. 131-133° C.