Picolyl chloride hydrochloride → (cis)-4-(3,4-Dimethoxyphenyl)-2-(2-pyridylmethyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C@H:20]3[C@H:15]([CH2:16][CH:17]=[CH:18][CH2:19]3)[C:14](=[O:21])[NH:13][N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].Cl.[N:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[CH2:29]Cl>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C@H:20]3[C@H:15]([CH2:16][CH:17]=[CH:18][CH2:19]3)[C:14](=[O:21])[N:13]([CH2:29][C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][N:23]=3)[N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]Komponenten
3
Versuchsvorschrift
Prepared from compound 3 and 2-picolylchloride hydrochloride as described for compound 105. Crystallized from diethyl ether. M.p. 146°-147° C.
Aufarbeitung
- customCrystallized from diethyl ether