Sodium Hydroxide → HCID 54529682, Verbindung

HRID 1871634Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1871634
[C:1]1([NH:7][CH:8]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][CH2:22][CH2:23][O:24][N:25]=[C:26]([C:28]3[CH:33]=[CH:32][C:31]([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][N:35]=4)=[CH:30][CH:29]=3)[CH3:27])=[CH:17][CH:16]=2)[C:9]([O:11]CC)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>>[C:1]1([NH:7][CH:8]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][CH2:22][CH2:23][O:24][N:25]=[C:26]([C:28]3[CH:29]=[CH:30][C:31]([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][N:35]=4)=[CH:32][CH:33]=3)[CH3:27])=[CH:17][CH:16]=2)[C:9]([OH:11])=[O:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

3

Edukt 2

HCID 14798Sodium HydroxideHCID 54509846HCID 54509846, Verbindung

Produkt 1

HCID 54529682HCID 54529682, VerbindungAusbeute 91 %

Versuchsvorschrift

The reaction was carried out according to Example 4 using 260 mg of ethyl 2-phenylamino-3-[4-[2-[[1-[4-(2-pyridyl)phenyl]ethylidene]aminoxy]ethoxy]phenyl]propionate obtained in Example 5 and 1.00 ml of a 1N aqueous sodium hydroxide solution. After the reaction, the reaction mixture was concentrated and diluted with water. The pH of the reaction mixture was adjusted to a value of 4 with 1N hydrochloric acid, and precipitate was obtained by filtration. The precipitate was washed with water and isopropyl ether to obtain 224 mg of the desired compound.

Aufarbeitung

  1. customAfter the reaction
  2. concentrationthe reaction mixture was concentrated
  3. additiondiluted with water
  4. customprecipitate was obtained by filtration
  5. washThe precipitate was washed with water and isopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-76016bf15f0043619959616f3f07e94e
Quelldatensatz
uspto-grants-2000_08
Patentnummer
US06103907

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