Potassium Iodide → HCID 15462192, Verbindung

HRID 1871926Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1871926
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:14]=[CH:13][C:12]([CH3:15])=[C:11]2[C:7]=1[C:8]([CH3:18])([CH3:17])[C:9](=[O:16])[NH:10]2.[N:19]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:22]=[CH:21][C:20]=1[CH:29]=[C:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1.C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CN(C=O)C>[N:19]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:22]=[CH:21][C:20]=1[CH:29]=[C:30]1[CH2:31][CH2:32][N:33]([CH2:2][CH2:3][CH2:4][O:5][C:6]2[CH:14]=[CH:13][C:12]([CH3:15])=[C:11]3[C:7]=2[C:8]([CH3:18])([CH3:17])[C:9](=[O:16])[NH:10]3)[CH2:34][CH2:35]1

Komponenten

6

Edukt 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 18689938HCID 18689938, VerbindungHCID 232910814-(3-Chloropropoxy)-3,3,7-trimethyl-2,3-dihydro-1H-indol-2-one

Produkt 1

HCID 15462192HCID 15462192, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

4-(3-Chloropropoxy)-3,3,7-trimethyl-2,3-dihydro-1H-indol-2-one (268 mg) and 4-(2-quinolylmethylene)piperidine (224 mg) were dissolved in DMF (10 ml), and potassium carbonate (145 mg) and potassium iodide (173 mg) were added to the solution. The mixture was stirred at 100° C. for 90 minutes under argon and concentrated under reduced pressure. Chloroform was added to the residue. The mixture was washed with water, dried over magnesium sulfate anhydrate, and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography (developer: chloroform-methanol (20:1)), to thereby obtain the title compound.

Aufarbeitung

  1. concentrationconcentrated under reduced pressure
  2. additionChloroform was added to the residue
  3. washThe mixture was washed with water
  4. dry with materialdried over magnesium sulfate anhydrate
  5. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-700237d52369492784eae6fdf6354ebc
Quelldatensatz
uspto-grants-2000_08
Patentnummer
US06107308

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