Triethylamine → HCID 86755649, Verbindung

Reaktionsgleichung

[C:1]([O:5][CH3:6])(=[O:4])[CH2:2][SH:3].[Cl:7][C:8]1[N:13]=[C:12](Cl)[C:11]([C:15]2[CH:20]=[CH:19][C:18]([CH2:21][C:22]([O:24][CH3:25])=[O:23])=[CH:17][CH:16]=2)=[CH:10][N:9]=1.C(N(CC)CC)C>O1CCCC1>[Cl:7][C:8]1[N:9]=[C:10]([S:3][CH2:2][C:1]([O:5][CH3:6])=[O:4])[C:11]([C:15]2[CH:16]=[CH:17][C:18]([CH2:21][C:22]([O:24][CH3:25])=[O:23])=[CH:19][CH:20]=2)=[CH:12][N:13]=1

Komponenten

Versuchsvorschrift

Methyl thioglycolate (0.18 ml) was added to a solution of the product from step (iii) (0.6 g) and triethylamine (0.56 ml) in tetrahydrofuran (10 ml) at room temperature. The mixture was stirred for 4 hours and partitioned between ethyl acetate and water. The organic phase was dried (MgSO4) and evaporated. Purification was by chromatography eluting with 20-30% ethyl acetate in isohexane. Yield 0.7 g.