Methanol → N-[2-[5-{2,8-Dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl}-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl]-5-[methoxycarbonyl]pyrimidin-4-yl]glycine

HRID 1871988Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1871988
[CH3:1][C:2]1[CH:44]=[CH:43][C:5]2[CH:6]([C:16]3[C:17](=[O:42])[NH:18][C:19](=[O:41])[N:20]([C:22]4[N:27]=[C:26]([NH:28][CH2:29][C:30]([O:32]C(C)(C)C)=[O:31])[C:25]([C:37]([O:39][CH3:40])=[O:38])=[CH:24][N:23]=4)[CH:21]=3)[C:7]3[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][C:8]=3[CH:9]=[CH:10][C:4]=2[CH:3]=1.CO>FC(F)(F)C(O)=O.ClCCl>[CH3:15][C:12]1[CH:13]=[CH:14][C:7]2[CH:6]([C:16]3[C:17](=[O:42])[NH:18][C:19](=[O:41])[N:20]([C:22]4[N:27]=[C:26]([NH:28][CH2:29][C:30]([OH:32])=[O:31])[C:25]([C:37]([O:39][CH3:40])=[O:38])=[CH:24][N:23]=4)[CH:21]=3)[C:5]3[CH:43]=[CH:44][C:2]([CH3:1])=[CH:3][C:4]=3[CH:10]=[CH:9][C:8]=2[CH:11]=1

Komponenten

5

Edukt 2

HCID 887MethanolHCID 867556552-[5-{2,8-Dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl}-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl]-4-[[[1,1-dimethylethoxy]carbonylmethyl]amino]-5-pyrimidinecarboxylic acid, methyl ester

Produkt 1

HCID 18689752N-[2-[5-{2,8-Dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl}-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl]-5-[methoxycarbonyl]pyrimidin-4-yl]glycine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

A mixture of the product of step (iii) (0.57 g) in trifluoroacetic acid (5 ml) and dichloromethane (10 ml) was stirred at room temperature for 5 hours. Methanol (30 ml) was added and the precipitate collected. The solid was dissolved in methanol and sodium hydroxide solution and the product precipitated out by addition of 2M HCl. Yield 0.26 g.

Aufarbeitung

  1. customthe precipitate collected
  2. dissolutionThe solid was dissolved in methanol
  3. customsodium hydroxide solution and the product precipitated out by addition of 2M HCl

Quellen und Nachweise

ORD-Eintrag
ord-fddf329857be4daf8cbe19cc593f37e6
Quelldatensatz
uspto-grants-2000_08
Patentnummer
US06107297

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