Cesium carbonate → HCID 86755658, Verbindung

HRID 1871994Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1871994
[CH2:1]([C:3]1[CH:27]=[CH:26][C:6]2[CH:7]([C:17]3[C:18]([S:24][CH3:25])=[N:19][C:20](=[O:23])[NH:21][CH:22]=3)[C:8]3[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:9]=3[CH:10]=[CH:11][C:5]=2[CH:4]=1)[CH3:2].F[C:29]1[CH:34]=[CH:33][N:32]=[C:31]([N:35]([CH3:51])[CH2:36][C:37]([NH:39][C:40]2[S:41][CH:42]=[C:43]([CH2:45][C:46]([O:48][CH2:49][CH3:50])=[O:47])[N:44]=2)=[O:38])[N:30]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>CN1CCCC1=O>[CH2:1]([C:3]1[CH:27]=[CH:26][C:6]2[CH:7]([C:17]3[C:18]([S:24][CH3:25])=[N:19][C:20](=[O:23])[N:21]([C:29]4[CH:34]=[CH:33][N:32]=[C:31]([N:35]([CH3:51])[CH2:36][C:37]([NH:39][C:40]5[S:41][CH:42]=[C:43]([CH2:45][C:46]([O:48][CH2:49][CH3:50])=[O:47])[N:44]=5)=[O:38])[N:30]=4)[CH:22]=3)[C:8]3[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:9]=3[CH:10]=[CH:11][C:5]=2[CH:4]=1)[CH3:2]

Komponenten

5

Edukt 3

HCID 10796Cesium carbonateHCID 86755657HCID 86755657, VerbindungHCID 178435472HCID 178435472, Verbindung

Produkt 1

HCID 86755658HCID 86755658, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 13387N-methyl-2-pyrrolidoneLösungsmittel

Versuchsvorschrift

The product of step (iv) (0.37 g), and the product of step (ii) (0.35 g) was stirred with cesium carbonate (0.32 g) in dry 1-methyl-2-pyrrolidinone (15 ml) at 65-70° C. for 20 hours. The reaction mixture was partitioned between ethyl acetate and brine. The organic layer collected, dried (MgSO4), and solvent evaporated under reduced pressure. Yield 0.61 g.

Aufarbeitung

  1. customThe reaction mixture was partitioned between ethyl acetate and brine
  2. customThe organic layer collected
  3. dry with materialdried (MgSO4), and solvent
  4. customevaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-1445cbdf53d5421b999b332b9a9d346b
Quelldatensatz
uspto-grants-2000_08
Patentnummer
US06107297

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