2-(Methylamino)ethanol → 2-chloro-4-methyl-6-(N-methyl-2-hydroxyethylamino)pyrimidine

HRID 1872033Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1872033
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([CH3:9])[N:3]=1.[CH3:10][NH:11][CH2:12][CH2:13][OH:14]>C(O)C>[Cl:1][C:2]1[N:3]=[C:4]([CH3:9])[CH:5]=[C:6]([N:11]([CH2:12][CH2:13][OH:14])[CH3:10])[N:7]=1

Komponenten

4

Edukt 2

HCID 80162-(Methylamino)ethanolHCID 794712,4-Dichloro-6-methylpyrimidine

Produkt 1

HCID 183238282-chloro-4-methyl-6-(N-methyl-2-hydroxyethylamino)pyrimidineAusbeute 34,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Part A: A solution of 2,4-dichloro-6-methylpyrimidine (1.0 g) and 2-(methylamino)ethanol (0.4 g) in ethanol (50 mL) was refluxed for 24 hours. The solvent was evaporated to give a crude residue, which was chromatographed on silica gel using 5% methanol in chloroform to yield 2-chloro-4-methyl-6-(N-methyl-2-hydroxyethylamino)pyrimidine (370 mg). Mass spec. (NH3 --CI/DDIP): 202 (M+H)+.

Aufarbeitung

  1. customThe solvent was evaporated
  2. customto give a crude residue, which
  3. customwas chromatographed on silica gel using 5% methanol in chloroform

Quellen und Nachweise

ORD-Eintrag
ord-9e53ef8df98649d09dae668c32ef2d97
Quelldatensatz
uspto-grants-2000_08
Patentnummer
US06107301

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