HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Chloro-4,6-dimethylpyrimidine → N-[3-bromo-5-methyl-pyridin-2-yl]-4,6-dimethyl-2-pyrimidinamine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Chloro-4,6-dimethylpyrimidine | HCID 20550 | — |
| Edukt | Sodium hydride | HCID 24758 | — |
| Edukt | 2-Amino-3-bromo-5-methylpyridine | HCID 519380 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | N-[3-bromo-5-methyl-pyridin-2-yl]-4,6-dimethyl-2-pyrimidinamine | HCID 18323693 | — |
Reaktionsschritte
Part A: A 1.0 gram (5.35 mmol) portion of commercially available 2 -amino-3-bromo-5-methylpyridine was coupled to 2-chloro-4,6-dimethylpyrimidine (Example 1, part A) using NaH (1.2 eq) in DMF to give N-[3-bromo-5-methyl-pyridin-2-yl]-4,6-dimethyl-2-pyrimidinamine. C12H13N4Br MS 293 (M+H)+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06107301 |
| Quelldatensatz | uspto-grants-2000_08 |
| ORD ID | ord-25cafadf87c842c1b63140ddd2950bae |
| Quellennotiz | uspto-grants-2000_08 |