HCID 18391989, Verbindung → (R)-(3-Pyrrolidineoxy)tetrahydro-2H-pyran

HRID 1872756Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1872756
C([N:8]1[CH2:12][CH2:11][C@@H:10]([O:13][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][O:15]2)[CH2:9]1)C1C=CC=CC=1>[OH-].[OH-].[Pd+2].CO>[O:15]1[CH2:16][CH2:17][CH2:18][CH2:19][CH:14]1[O:13][C@@H:10]1[CH2:11][CH2:12][NH:8][CH2:9]1

Komponenten

4

Edukt 1

HCID 18391989HCID 18391989, Verbindung

Produkt 1

HCID 18392016(R)-(3-Pyrrolidineoxy)tetrahydro-2H-pyranAusbeute 122,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 1-benzyl-3-(R)-tetrahydropyranyloxypyrrolidine (8.78 g, 27.3 mmol) and Pearlman's catalyst (3.50 g) in MeOH (100 ml) was stirred under hydrogen atmosphere at rt for 4 h. After removal of the catalyst by Celite filtration, the filtrate was concentrated to give 5.74 g of clear light brown oil. This was used for the next reaction without purification.

Aufarbeitung

  1. customAfter removal of the catalyst
  2. filtrationby Celite filtration
  3. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-0dc481014de54bd2ae67a0767e3883f4
Quelldatensatz
uspto-grants-2000_08
Patentnummer
US06110947

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