Ethyl isothiocyanatoformate → Ethyl {[(5-{3-[(tert-butoxycarbonyl)amino]-4-chlorophenoxy}pyridin-2-yl)amino]carbonothioyl}carbamate

HRID 1874374

Reaktionsgleichung

Reaktionsgleichung von HRID 1874374
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([O:8][C:9]2[CH:10]=[CH:11][C:12]([Cl:23])=[C:13]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])[CH:14]=2)=[CH:4][CH:3]=1.[N:24]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[C:25]=[S:26]>CS(C)=O>[C:18]([O:17][C:16]([NH:15][C:13]1[CH:14]=[C:9]([CH:10]=[CH:11][C:12]=1[Cl:23])[O:8][C:5]1[CH:4]=[CH:3][C:2]([NH:1][C:25]([NH:24][C:27](=[O:28])[O:29][CH2:30][CH3:31])=[S:26])=[N:7][CH:6]=1)=[O:22])([CH3:19])([CH3:20])[CH3:21]

Komponenten

4

Edukt 2

HCID 85320Ethyl isothiocyanatoformateHCID 57749356Tert-butyl {5-[(6-aminopyridin-3-yl)oxy]-2-chlorophenyl}carbamate

Produkt 1

HCID 57749196Ethyl {[(5-{3-[(tert-butoxycarbonyl)amino]-4-chlorophenoxy}pyridin-2-yl)amino]carbonothioyl}carbamateAusbeute 97 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

In the same manner as in Reference Example 30 and using tert-butyl {5-[(6-aminopyridin-3-yl)oxy]-2-chlorophenyl}carbamate (10.8 g, 32.3 mmol), ethyl isothiocyanatoformate (4.60 mL, 38.9 mmol) and DMSO (60 mL) as starting materials, the title compound (14.6 g, 97%) was obtained as a pale-yellow oil.

Quellen und Nachweise

ORD-Eintrag
ord-c2f8746ad1974d088988415eca8f1753
Quelldatensatz
uspto-grants-2012_11
Patentnummer
US08304557B2

Verknüpfte Notizen

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