p-Toluenesulfonic acid monohydrate → N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide p-toluenesulfonate

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a solution of N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (204 mg, 0.474 mmol) in ethanol (8 mL) was added a solution of p-toluenesulfonic acid monohydrate (94.7 mg, 0.498 mmol) in ethyl acetate (1.10 mL), and the mixture was stirred at 0° C. for 2 hr and at room temperature for 2 days. The precipitated solid was collected by filtration and washed with ethanol to give the title compound (192 mg, 67%) as a white solid.

Herkunft & Nachweise