Hydrochloric Acid → Methyl (4R)-4-[(2-ethoxy-7-methoxy-6-vinylquinolin-4-yl)oxy]-L-prolinate dihydrochloride
Reaktionsgleichung
[ClH:1].[CH2:2]([O:4][C:5]1[CH:14]=[C:13]([O:15][C@H:16]2[CH2:20][N:19](C(OC(C)(C)C)=O)[C@H:18]([C:28]([O:30][CH3:31])=[O:29])[CH2:17]2)[C:12]2[C:7](=[CH:8][C:9]([O:34][CH3:35])=[C:10]([CH:32]=[CH2:33])[CH:11]=2)[N:6]=1)[CH3:3]>C(Cl)Cl>[ClH:1].[ClH:1].[CH2:2]([O:4][C:5]1[CH:14]=[C:13]([O:15][C@H:16]2[CH2:20][NH:19][C@H:18]([C:28]([O:30][CH3:31])=[O:29])[CH2:17]2)[C:12]2[C:7](=[CH:8][C:9]([O:34][CH3:35])=[C:10]([CH:32]=[CH2:33])[CH:11]=2)[N:6]=1)[CH3:3]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
HCl (g) was bubbled for 10 minutes through a solution of the product from Step 1 (3.90 g, 8.25 mmol) in DCM (83 mL). The solution stirred for 1 hour, and the DCM was removed in vacuo to give 3.55 g of the title compound as a white powder. LRMS ESI+ (M+H−2(HCl))+ 373.1, calcd for C20H25N2O5: 373.2.