4-(Bromomethyl)-3-fluorobenzonitrile → HCID 67049937, Verbindung
Reaktionsgleichung
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:9]2[N:13]([CH2:14][C:15]([CH3:18])([CH3:17])[CH3:16])[C:12]3[CH:19]=[C:20]([F:24])[C:21]([F:23])=[CH:22][C:11]=3[N:10]=2)=[C:6]([OH:8])[CH:7]=1.Br[CH2:26][C:27]1[CH:34]=[CH:33][C:30]([C:31]#[N:32])=[CH:29][C:28]=1[F:35]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:9]2[N:13]([CH2:14][C:15]([CH3:18])([CH3:17])[CH3:16])[C:12]3[CH:19]=[C:20]([F:24])[C:21]([F:23])=[CH:22][C:11]=3[N:10]=2)=[C:6]([CH:7]=1)[O:8][CH2:26][C:27]1[CH:34]=[CH:33][C:30]([C:31]#[N:32])=[CH:29][C:28]=1[F:35]Komponenten
3
Versuchsvorschrift
The title compound was prepared in analogy to Example 5, intermediate a, from 5-chloro-2-[1-(2,2-dimethyl-propyl)-5,6-difluoro-1H-benzoimidazol-2-yl]-phenol and 4-bromomethyl-3-fluoro-benzonitrile (CAS Reg. No. 105942-09-4). Light brown solid (95%). MS (Turbo Spray): m/z=483.8 (M+H).
Quellen und Nachweise
- ORD-Eintrag
- ord-57baf38d16024311a7754f74d4622eb3
- Quelldatensatz
- uspto-grants-2012_11