Benzenamine, N,4-dimethyl- → 4-Quinazolinamine, 2-chloro-N-methyl-N-(4-methylphenyl)-

HRID 1876055

Reaktionsgleichung

Reaktionsgleichung von HRID 1876055
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:13][C:14]1[CH:21]=[CH:20][C:17]([NH:18][CH3:19])=[CH:16][CH:15]=1>>[Cl:1][C:2]1[N:11]=[C:10]([N:18]([C:17]2[CH:20]=[CH:21][C:14]([CH3:13])=[CH:15][CH:16]=2)[CH3:19])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Komponenten

3

Edukt 2

HCID 12165Benzenamine, N,4-dimethyl-HCID 2528862,4-Dichloroquinazoline

Produkt 1

HCID 112660784-Quinazolinamine, 2-chloro-N-methyl-N-(4-methylphenyl)-

Versuchsvorschrift

The title compound was prepared from 2,4-dichloroquinazoline (250 mg, 1.25 mmol) and 4-methyl-N-methylaniline (196 mg, 1.43 mmol) by a procedure similar to Example 1b and was isolated as white powder (210 mg, 84%). 1H NMR (CDCl3): 8.69 (d, J=8.4 Hz, 1H), 7.75 (dd, J=8.1 and 7.5 Hz, 1H), 7.39 (d, J=7.8 Hz, 2H), 7.25 (d, J=7.8 Hz, 2H), 7.13 (d, J=8.2 Hz, 1H), 6.74 (d, J=8.7 Hz, 1H), 3.81 (s, 3H), 2.49 (s, 3H).

Quellen und Nachweise

ORD-Eintrag
ord-b141b636d71a43adbd1066cd9f641f18
Quelldatensatz
uspto-grants-2012_11
Patentnummer
US08309562B2

Verknüpfte Notizen

Wird geladen…